PUMA Polyclonal Antibody, 20ul Antisense Oligonucleotides RCC2/TD-60 is a member of

RCC2/TD-60 is a member of the RCC1 (regulator of chromosome condensation 1) family of guanine nucleotide exchange factors

An important paralog of this gene is TAOK1

High levels of this protein and RIP3 are associated with inflammatory bowel disease in children

a disease caused by degeneration of the cerebellum

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PUMA Polyclonal Antibody, 20ul Antisense Oligonucleotides RCC2/TD-60 is a member ofBBC3 encodes a member of the BCL 2 family of proteins. This family member belongs to the BH3 only pro apoptotic subclass. BCL2 binding component 3 cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti apoptotic Bcl 2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro apoptotic role, BBC3 is a potential drug target for cancer