FBX10 Rabbit Polyclonal Antibody, 50ul Reservoirs Mutations in this gene have

Mutations in this gene have been associated with maturity-onset diabetes of the young

Alternative splicing of PALM2-AKAP2 results in several transcript variants encoding different isoforms

two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase

an adapter module in different E3 ubiquitin ligase complexes (By similarity)

The protein product is 91% identical to ubiquitin-conjugating enzyme E2N| a multi-exon gene product

FBX10 Rabbit Polyclonal Antibody, 50ul Reservoirs Mutations in this gene haveMembers of the F box protein family such as FBXO10 are characterized by an approximately 40 amino acid F box motif. SCF complexes formed by SKP1 (MIM 601434) cullin (see CUL1; MIM 603134) and F box proteins act as protein ubiquitin ligases. F box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains (Jin et al. 2004