CD110 Polyclonal Antibody, 50ul[BT-AP01341] Endonucleases & Exonucleases TOP2A encoding this enzyme functions

TOP2A encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance

subunit:Interacts with RAB6KIFL

The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus

RPS25 (ribosomal protein S25) encodes a ribosomal protein that is a component of the 40S subunit

Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed: 20074560)

CD110 Polyclonal Antibody, 50ul[BT-AP01341] Endonucleases & Exonucleases TOP2A encoding this enzyme functionsIn 1990 an oncogene, v mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c mpl, was cloned. Sequence data revealed that c mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti sense oligodeoxynucleotides of c mpl inhibited megakaryocyte colony