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The architecture of its extracellular domain is similar to that of neurexins

2002 [PubMed 11923475])

The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome

ILK Polyclonal Antibody, 100ul Molecular Sciences Take on anything with ourILK encodes a protein with a kinase like domain and four ankyrin like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript