Jak3(Phospho-Tyr980/981) Rabbit Polyclonal Antibody, 20ul Fluorescent Staining Two alternately spliced transcript variants

Two alternately spliced transcript variants of MAPKAPK5 encoding distinct isoforms have been reported

All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'

Defects in this gene are a cause of childhood cancer retinoblastoma (RB)

Required for the actin rearrangement at cell-cell junctions

The majority of zinc-finger proteins contain a Krueppel-type DNA binding domain and a KRAB domain

Jak3(Phospho-Tyr980/981) Rabbit Polyclonal Antibody, 20ul Fluorescent Staining Two alternately spliced transcript variantsThe protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).