Tuberin Polyclonal Antibody, 50ul[BT-AP09286] Protein Research The first step involves recognition

The first step involves recognition of the TATA element by the TATA-binding subunit (TBP

and it is required for the association of centromere-associated protein E with the kinetochore

its full-length nature is not known

Mutations at this locus have been linked to autosomal recessive deafness

Interacts with RNF43

Tuberin Polyclonal Antibody, 50ul[BT-AP09286] Protein Research The first step involves recognitionMutations in TSC2 (tuberous sclerosis 2) lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.