ZHX2 Polyclonal Antibody, 20ul Buffers & Solutions Mutations in this gene have

Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS)

Heterodimers consisting of alpha and gamma subunits have also been described

It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas

It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA

A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters

ZHX2 Polyclonal Antibody, 20ul Buffers & Solutions Mutations in this gene haveThe members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor Y (NF YA) and contain two C2H2 type zinc fingers and five homeobox DNA binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.