ATR Polyclonal Antibody, 50ul Centrifuges It is located in the

It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting

The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein

Catalytic activity:Release of a C-terminal amino acid with broad specificity

Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome

Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins

ATR Polyclonal Antibody, 50ul Centrifuges It is located in theThe protein encoded by ATR (ATR serine threonine kinase) belongs the PI3 PI4 kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1,