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Human Norrin, NDP ELISA Kit , 96T Plasmid Preparation The encoded protein is a

SKU: 30362391947

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Human Norrin, NDP ELISA Kit , 96T Plasmid Preparation The encoded protein is aActivates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta catenin (CTNNB1) and activating LEF TCF mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt dependent activation of FZD4, suggesting the existence of a Wnt independent signaling that also promote accumulation

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Description

The encoded protein is a member of the T-box 1 subfamily

Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed: 6334084)

which is a member of the MAGE family

It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains

or themselves act are protease enzymes

Human Norrin, NDP ELISA Kit , 96T Plasmid Preparation The encoded protein is aActivates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta catenin (CTNNB1) and activating LEF TCF mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt dependent activation of FZD4, suggesting the existence of a Wnt independent signaling that also promote accumulation

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