XIAP Polyclonal Antibody, 20ul CellSafe™ The leucine zipper down-regulated in

The leucine zipper down-regulated in cancer 1 encoded by LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain

This gene encodes the gamma chain isoform laminin

a single transmembrane segment and two tandem intracytoplasmic catalytic domains

The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin

The antigen is being used as a target for immunotherapy treatment of human carcinomas

XIAP Polyclonal Antibody, 20ul CellSafe™ The leucine zipper down-regulated inXIAP encodes E3 ubiquitin protein ligase XIAP that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti apoptotic function. This protein functions through binding to tumor necrosis factor receptor associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1 beta