AAT1 Polyclonal Antibody, 20ul Pathway and Network Analysis Liprin-beta-1 encoded by PPFIBP1 is

Liprin-beta-1 encoded by PPFIBP1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family

The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond

Mutations in this gene have been linked with Li-Fraumeni syndrome| a highly penetrant familial cancer phenotype usually associated with inherited mutati

but activates transcription when Ras is present

and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types

AAT1 Polyclonal Antibody, 20ul Pathway and Network Analysis Liprin-beta-1 encoded by PPFIBP1 isalternative products: Additional isoforms (AAT 1L and AAT 1S) may exist Isoform 4 may play a role in spermatogenesis. PTM: Isoform 4 is phosphorylated by PKA. subcellular location: Isoform 4 is found in the mitochondria and localized in the neck of the sperm. subunit: Interacts with AMY1 and AKAP1. Isoform 4 belongs to a complex together with AMY1 AKAP1 and PRKAR2B. Isoform 3 does not interact with AMY1. tissue specificity: Isoform 1 is strongly