Histone deacetylase 6 Polyclonal Antibody, 100ul Pipette Holder Defects in this gene have

Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family| but not in similar patients of European descent

Mutations in the gene cause Sjogren-Larsson syndrome

The beta cluster contains 16 genes and 3 pseudogenes| each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily

The long form is expressed in steroidogenic tissues such as testis

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles

Histone deacetylase 6 Polyclonal Antibody, 100ul Pipette Holder Defects in this gene haveHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 6 encoded by HDAC6 belongs to class II of the histone deacetylase acuc apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein