TAB3 Polyclonal Antibody, 20ul ssDNA Synthesis Constitutive activation of PRKACA caused

Constitutive activation of PRKACA caused either by somatic mutations

This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation

which may function as a transcription factor

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The encoded protein (cadherin 19) is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats

TAB3 Polyclonal Antibody, 20ul ssDNA Synthesis Constitutive activation of PRKACA causedThe product of this gene functions in the NF kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2 TAB2, forms a ternary complex with the protein kinase MAP3K7 TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro inflammatory cytokines TNF or IL 1. Subsequent MAP3K7 TAK1 kinase activity triggers a signaling cascade leading to activation of the NF kappaB transcription