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Paxillin Polyclonal Antibody, 50ul[BT-AP06955] Sampling Tubes This gene encodes the non-catalytic

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Paxillin Polyclonal Antibody, 50ul[BT-AP06955] Sampling Tubes This gene encodes the non-catalyticPXN encodes a cytoskeletal protein involved in actin membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for PXN. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties.

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Description

This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase| a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine)

This receptor/ligand complex phosphorylates proteins

The protein encoded by KRT19 is a member of the keratin family

Alternatively spliced transcript variants encoding distinct isoforms have been found

A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres

Paxillin Polyclonal Antibody, 50ul[BT-AP06955] Sampling Tubes This gene encodes the non-catalyticPXN encodes a cytoskeletal protein involved in actin membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for PXN. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties.

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