Human Interleukin-1 Receptor-associated Kinase 1, IRAK1 ELISA Kit, 96T Molecular Weight Markers suggesting an involvement in the

suggesting an involvement in the regulation of processes such as cell survival

Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits

The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells

PubMed: 10684867

C-terminal

Human Interleukin-1 Receptor-associated Kinase 1, IRAK1 ELISA Kit, 96T Molecular Weight Markers suggesting an involvement in theSerine threonine protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll like receptor (TLR) and IL 1R signaling pathways. Is rapidly recruited by MYD88 to the receptor signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins