CD6 Polyclonal Antibody, 50ul[BT-AP02235] Digital Burette It was also found to

It was also found to be expressed in several cancer cell lines| but not in the corresponding normal tissues

and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion

Disruption of this gene has been implicated in Carpenter syndrome as well as cancer

When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner

This gene is expressed in both normal and tumor cells

CD6 Polyclonal Antibody, 50ul[BT-AP02235] Digital Burette It was also found toCRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS dependent fashion. It is a substrate of the BCR ABL tyrosine kinase, plays a role in fibroblast transformation by BCR ABL, and may be oncogenic.