HXB7 Polyclonal Antibody, 100ul Site-directed Mutagenesis GPR116 is a gene on

GPR116 is a gene on chromosome 6p12

It is a neural recognition molecule that may be involved in signal transduction pathways

Mutations in this gene are associated with two types of recessive osteochondrodysplasia| Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia| which involve both skeletal defects and mental retardation

Alternativley spliced transcript variants encoding different isoforms have been identified in this gene

6-hexakisphosphate (InsP6)

HXB7 Polyclonal Antibody, 100ul Site-directed Mutagenesis GPR116 is a gene onThis gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.