Tie-2(Phospho Tyr1108) Polyclonal Antibody, 20ul ADME In mice| the disabled-1 gene

In mice| the disabled-1 gene plays a central role in brain development| directing the migration of cortical neurons past previously formed neurons to reach their proper layer

Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities

Reciprocal translocations between chromosomes 17 and 22| where this gene and the gene for platelet-derived growth factor beta are located| are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans| resulting from unregulated expression of the growth factor

The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein

a disorder resulting in neuropathy

Tie-2(Phospho Tyr1108) Polyclonal Antibody, 20ul ADME In mice| the disabled-1 geneThis gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin like domains, three epidermal growth factor (EGF) like domains and three fibronectin type III repeats. The ligand angiopoietin 1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated