Tuberin/TSC2(Phospho-Ser1254) Rabbit Polyclonal Antibody, 100ul Hybridoma Antibody Sequencing |tissue specificity:Plasma

|tissue specificity:Plasma

A heterodimer of this Runt-related transcription factor 3 and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters

Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS)

Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes

The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles

Tuberin/TSC2(Phospho-Ser1254) Rabbit Polyclonal Antibody, 100ul Hybridoma Antibody Sequencing |tissue specificity:PlasmaMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.