Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes This gene is highly expressed

This gene is highly expressed in the brain and may function as an integrin ligand in the brain

subcellular location:Colocalizes with a lysosomal protein cathepsin D

have an additional cyclin binding domain

extracellular matrix proteases modulating their activity

Binds to a consensus sequence in gene promoters (By similarity)

Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes This gene is highly expressedReleases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA (3' phosphotyrosyl) enzyme intermediate and the expulsion of a 5' OH