Rat Beta-Arrestin-2, ARRB2 ELISA Kit, 96T Cell Function Analysis It may be part of

It may be part of a physiologic ligand-receptor complex involved in T-cell activation

Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed: 15870257

a ubiquitin-like protein

Deconjugates SUMO2 from MTA1 (PubMed: 21965678)

Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed: 26711253)

Rat Beta-Arrestin-2, ARRB2 ELISA Kit, 96T Cell Function Analysis It may be part ofFunctions in regulating agonist mediated G protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta arrestins bind to the GPRK phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta arrestins target