Nibrin(Phospho Ser278) Polyclonal Antibody, 100ul Plasmid Preparation Negatively regulates aortic matrix metalloproteinase-9

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling

is retained in cytoplasm by YWHAZ

This gene is part of a 500 kb inverted duplication on chromosome 5q13

located between domains C and E

Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11)

Nibrin(Phospho Ser278) Polyclonal Antibody, 100ul Plasmid Preparation Negatively regulates aortic matrix metalloproteinase-9Mutations in this gene are associated with Nijmegen breakage syndrome an autosomal recessive chromosomal instability syndrome characterized by microcephaly growth retardation immunodeficiency and cancer predisposition. The encoded protein is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint