Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing Plays an essential role in

Plays an essential role in autophagy

This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus

It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism

suppressed by proinflammatory mediators like lipopolysaccharide (LPS)| Interferon gamma/IFNG| and tumor necrosis factor alpha

including those that encode for chemokines

Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing Plays an essential role inThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF beta receptor type 1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding