Rb Polyclonal Antibody, 100ul[BT-AP07694] Electrophoresis & Labeling All semaphorins possess a semaphorin

All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins

Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified

or with the remaining 2 exons unique to PEG3

transferring phosphorus-containing groups and protein tyrosine kinase activity

The encoded protein (EPS8 like 2)

Rb Polyclonal Antibody, 100ul[BT-AP07694] Electrophoresis & Labeling All semaphorins possess a semaphorinThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.