TAGL Polyclonal Antibody, 100ul Cell Function Analysis the ubiquitin ligase activity being

the ubiquitin ligase activity being mediated by RBX1

and due to amplification

This gene is a member of the M-phase phosphoprotein (MPP) family

Heterozygous mutations in the this gene cause auditory-pigmentary syndromes

to DNA-damage foci

TAGL Polyclonal Antibody, 100ul Cell Function Analysis the ubiquitin ligase activity beingThe protein encoded by this gene is a transformation and shape change sensitive actin cross linking gelling protein found in fibroblasts and smooth muscle. Its expression is down regulated in many cell lines, and this down regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.