SFRP1 Polyclonal Antibody, 20ul Protein Expression UNC-51-like kinase 1 and 2

UNC-51-like kinase 1 and 2 (ULK1

also known as epilepsy

The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus

Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase

Mutations in this gene have been associated with geleophysic dysplasia

SFRP1 Polyclonal Antibody, 20ul Protein Expression UNC-51-like kinase 1 and 2This gene encodes a member of the SFRP family that contains a cysteine rich domain homologous to the putative Wnt binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.